Cancer : Fifteen Warning Symptoms

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Cancer : Fifteen Warning Symptoms

1. Losing weight at a rapid rate (among people not being on a diet), gasses, discomfort, digestive disorders, anorexia, recurring diarrhea, constipation are the symptoms occurring most frequently in cases of lung, stomach, kidney and large intestine cancer.

If accompanied by a feeling of weakness, it can be a sign of blood loss or lack of proper elements building it.

2. Pain of unknown cause long-lasting stomach-ache can be the symptom of large intestine cancer, lumbalgia can be the sign of kidney cancer, pain in the chest can result from lung cancer. Bone aches can be caused by metastasis.

3. Haemoptysis, long-lasting hoarseness (over 3 weeks), persistent cough or change of its character can be caused by lung or larynx cancer.

4. Change in colour of moles and warts, ulceration and itching, ulceration of open wounds, burns and scalds can be the signs of skin cancer.

5. Excessive production of urine, backlog of urine, painful urinating, slow, time-consuming flow of urine, lumbago as well as backache can be the signs of prostate cancer.

6. Pain, vertigo, nausea, sight distortions (oversensitized sight, astigmatism), hearing impediment, upset balance and mental disorders can result from brain cancer.

7. Swallowing difficulties can be a symptom of throat, larynx, oesophagus and stomach cancer.

8. Feeling of fullness in epigastrium, aches and digestive disorders may be due to stomach cancer and other kinds of alimentary canal cancer, sometimes ovary cancer.

9. Blood in faeces, black faeces, alternating diarrhoea and constipation, mucus in faeces, narrow (pencil-like) faeces are the symptoms of alimentary canal cancer, especially of large intestine and rectum.

10. Blood in urine (without the symptoms of urinary tracks inflammation), dysuria (compulsive urination, difficulties in urination) can accompany the urinary tracks cancer.

11. Improper bleeding from the genital tracks, pink or dark-red vaginal discharges, hypogastrium and lower limbs ache can be the signs of vagina, uterine cervix and uterus cancer.

12. Marks on skin and mucosus membrane (lips, oral cavity, genitals): not healing ulceration, change in appearance, occurrence of new skin marks of some specific features (irregular distribution of pigment, vague line between the mark and healthy skin, quick growth of the marks, bleeding, dripping).

13. Breast tumour (by approximately 15% – 25% can be impalpable), ulceration, the retraction of nipple, asymmetrical nipples, change of size or the shape of a nipple, its swelling and the marks around it, enlargement of lymphatic glands in the armpit, extension of veins in the breast skin, ulceration of breast skin, shoulder swelling, flat efflorescene in case of the so called advanced inflammation nipple cancer are often the symptoms of breast cancer.

14. Fever, tiredness, bones and joints ache, inclination to temporary anaemia and bleeding, impalpable tumour of abdominal cavity, as a result of spleen enlargement, that can be detected in gastro-bowel test.

15. Pain and pressure in the upper right part of stomach, tiredness, anorexia and at a further stage of rhe disease a palpable tumour in the upper right part of stomach, inclination to jaundice and bleeding can be the signs of liver cancer.

Radoslaw Pilarski

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US clears Pfizer drug for advanced kidney cancer

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US clears Pfizer drug for advanced kidney cancer

WASHINGTON (AP) Patients with hard-to-treat kidney cancer that has spread to other parts of the body gained a new drug option Friday, after U.S. government regulators approved a twice-a-day pill from Pfizer for the disease.

The Food and Drug Administration approved the company’s drug Inlyta as a secondary option for patients with renal cell carcinoma that hasn’t responded to previous drug treatments. Renal cell carcinoma is the most common form of kidney cancer, with an estimated 61,000 people in the U.S. newly diagnosed last year, according to the National Cancer Institute. Only about 11 percent of patients with advanced kidney cancer survive five years or more after diagnosis.

Like other recent cancer drugs, Inlyta works by blocking proteins that promote tumor growth and cancer progression.

The market for kidney cancer drugs has grown increasingly crowded in recent years, with six other new drugs approved in the last six years, including Roche’s Avastin and GlaxoSmithKline’s Votrient. Pfizer’s drug is only the second to be designated as a backup, or second-line, treatment after other kidney cancer drugs have been prescribed. Pfizer is also conducting studies of the drug as a first-line option against kidney cancer.

“This is the seventh drug that has been approved for the treatment of metastatic or advanced kidney cell cancer since 2005,” said Dr. Richard Pazdur, FDA’s cancer drug director, in a statement. “Collectively, this unprecedented level of drug development within this time period has significantly altered the treatment paradigm.”

The FDA approved the drug based on a single study in which patients on Inlyta, known chemically as axitinib, experienced two more months without their cancer worsening than patients taking Nexavar, a drug from Bayer and Onyx Pharmaceuticals.

The most common side effects with Inlyta included diarrhea, high blood pressure, fatigue, nausea, weight loss and decreased appetite, among others.

“Even with the advent of targeted therapies, the need remains for additional options for patients with advanced renal cell carcinoma whose disease has progressed following first-line medications,” Pfizer Senior Vice President Dr. Mace Rothenberg said in a statement.

Shares of New York-based Pfizer Inc. fell 12 cents to $21.51 in afternoon trading.

By MATTHEW PERRONE

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